Subgroup 2 . Skin Irritation / Corrosion
نویسندگان
چکیده
ECVAM, Institute for Health & Consumer Protection, European Commission Joint Research Centre, 21020 Ispra (VA), Italy; EVIC FRANCE,33290 Blanquefort, France; Syngenta, Central Toxicology Laboratory, Alderley Park, Macclesfield, Cheshire SK10 4TJ, UK; SEAC, Unilever Colworth Laboratory, Sharnbrook Bedfordshire MK44 1LQ,,UK; ZEBET BfR, Diedersdorfer Weg 1, 12277 Berlin, Germany; TNO Nutrition & Food Research, Department of Explanatory Toxicology, Utrechtseweg 48, 3700 AJ Zeist, The Netherlands.
منابع مشابه
Alternative methods for skin irritation testing: the current status.
The potential for chemicals to cause skin corrosion or skin irritation is an important consideration in establishing procedures for the safe handling, packing and transport of chemicals. The determination of skin corrosion and irritation potential is therefore included in international regulatory requirements for the testing of chemicals. The standard approach used involves applying the test ma...
متن کاملGenotoxicity, acute oral and dermal toxicity, eye and dermal irritation and corrosion and skin sensitisation evaluation of silver nanoparticles.
To clarify the health risks related to silver nanoparticles (Ag-NPs), we evaluated the genotoxicity, acute oral and dermal toxicity, eye irritation, dermal irritation and corrosion and skin sensitisation of commercially manufactured Ag-NPs according to the OECD test guidelines and GLP. The Ag-NPs were not found to induce genotoxicity in a bacterial reverse mutation test and chromosomal aberrati...
متن کاملSkin corrosion and irritation test of sunscreen nanoparticles using reconstructed 3D human skin model
OBJECTIVES Effects of nanoparticles including zinc oxide nanoparticles, titanium oxide nanoparticles, and their mixtures on skin corrosion and irritation were investigated by using in vitro 3D human skin models (KeraSkin ((TM)) ) and the results were compared to those of an in vivo animal test. METHODS Skin models were incubated with nanoparticles for a definite time period and cell viability...
متن کاملSkin Corrosion and Irritation Test of Nanoparticles Using Reconstructed Three-Dimensional Human Skin Model, EpiDermTM
Effects of nanoparticles (NPs) on skin corrosion and irritation using three-dimensional human skin models were investigated based on the test guidelines of Organization for Economic Co-operation and Development (OECD TG431 and TG439). EpiDermTM skin was incubated with NPs including those harboring iron (FeNPs), aluminum oxide (AlNPs), titanium oxide (TNPs), and silver (AgNPs) for a defined time...
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